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I'm afraid that there is no solution..
There is lot's of people reporting problems with W10 and Prolific devices (based on popular PL2303 adapter).
Myself, I've the same problems with scrolling LED Badges, and USB to COM dongles. All this devices use a PL2303 to provide a connection to an USB port, but inside, they are RS232-like interface build (and appear as a COM port in your operating system). When you plug the device into USB, it is well recognized by W10 and it try to load the Prolific driver. This work fine, but looking at the configuration panel, you will then notice that there is an error code 10 and the driver is not working properly. Berserk story arcs.

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Of course, you can try to manually update the driver at Prolific site:

This serial cable is a bridge that links the traditional serial (DB9) interface to the Universal Serial Bus (USB) interface. It is easy to install. Downloadable Content: Driver Parts Warranty: 90 Da. USB to Serial Adapter (RS-232) The USB to Serial RS-232 Adapter provides one RS-232 Serial (DB-9 male) connector via one standard USB port at a data transfer rate of up to 230Kbps. You can instantly enjoy connectivity with modem, PDA, POS, or other serial devices on your PC or Mac without the hassle of opening your computer case. To manually install the USB to Serial drivers on Windows Vista 64-bit operating systems. Select Locate and install driver software. If the driver isn't found automatically, select Don't have a disc. Show more options. Select Browse my computer for drive software.

Usb midi driver for windows. KORG USB-MIDI Driver/KORG USB-MIDI Driver (for Windows 10) Version：1.15 r31e Date：2019.07.19. KORG USB MIDI Driver for Windows Release notes. New products: B2/B2SP/B2N, Supports Windows 10 May 2019 Update (V1903) Click here for previous versions. The USB-MIDI Driver is for use with Studio Manager V2 Host, Editor, PM1D Manager and DME Designer. Be sure to use the latest versions of the software available on this Yamaha Pro Audio site. Please download   32-bit driver   when you use 32-bit Windows. Main Revisions and Enhancements. Tech Tip: If you are having trouble deciding which is the right driver, try the Driver Update Utility for Casio USB MIDI. It is a software utility that will find the right driver for you - automatically. DriverGuide maintains an extensive archive of Windows drivers available for free download. We employ a team from around the world.

But, look carefully on this page and you will read an important notice in RED :

Drivers Usb To Serial Windows 10

Download windows dvd maker microsoft. Windows 8/8.1/10 are NOT supported in PL-2303HXA and PL-2303XEOL (End Of Life) chip versions.

USB-RS232 Serial Converter Driver Download. Windows 7 64-bit & 32-bit, Windows Vista 64-bit & 32-bit, Windows XP, Windows 2000, Windows Me, Windows 98. Important note regarding Windows 7 and Vista: The driver MUST be installed 'as Administrator' Right-click the downloaded EXE file and choose Run as administrator. Apr 20, 2017  In Windows 8.1 and earlier versions of the operating system, Usbser.sys is not automatically loaded when a USB-to-serial device is attached to a computer. To load the driver, you need to write an INF that references the modem INF (mdmcpq.inf) by using the Include directive.

This is clear: if your device is using an old chip version of PL2303, the drivers not works with W10 (and W8).

As many people, you probably upgrade directly from W7 to W10, and sure, don't know that this problem was already present with W8. It's a shame from Prolific to not support this devices, because they are still used (my LED badges are less than a year old, and use EOL PL-2303 HX). Prolific's guys are fun when they said : 'Prolific recommends to use PL-2303HXD (HX Rev D) or PL2303TA chip.' . Hey, but I can't do that myself !!!

Drivers For Usb To Serial Cable

I don't want to send my devices to trash because they are too old (less than a year !) to be supported by W10.
May be, a solution will be to use the old W7 drivers version into W10. Not tested.. I will try..